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It is considered a mitochondrial-derived peptide (MDP) and functions as a metabolic regulator

This is important because it suggests the anti-psoriatic activity can be localized to a specific portion of the larger protein, potentially allowing the development of small, targeted peptide therapeutics

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A classic pharmacokinetic study in the Annals of Internal Medicine (Levine et al., 2004) found that a modeled 50 g IV dose produced peak plasma levels around 13,400 mol/L, versus 220 mol/L for the maximum tolerated oral regimen roughly 3070 times higher plasma concentrations with IV administration

What this regulatory shift may enable is a more structured environment for clinical research