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Copper(II) ions are essential for the activity of lysyl oxidase, the enzyme that catalyzes the covalent cross-linking of collagen and elastin fibers

Individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN2) should discuss this with their clinician before considering any GLP-1based therapy, and should be alert to symptoms such as a neck lump, hoarseness, or difficulty swallowing

10.1007/s40262-016-0488-y 195 TangW.YuF.YaoH.CuiX.JiaoY.LinL.et al (2014)