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Food reduces that number even further, potentially cutting absorption by more than 50%

What Some Of The Evidence Shows So Far To date, there are no randomised or prospective studies testing GLP-1 cycling for weight maintenance or long term management

The ideal candidate has undergone bariatric surgery at least one year prior, maintains a stable weight (even if higher than goal), demonstrates renewed appetite or eating behavior challenges, and has no contraindications like unresolved nutritional deficiencies

Ratio Improvement: Despite absolute muscle loss, the STEP 1 trial showed that the proportion of lean mass relative to total body weight actually increased

If you or someone you love is struggling with alcohol use and also meets criteria for a GLP-1 prescription (typically type 2 diabetes or a BMI over 30), its worth having a conversation with a healthcare provider about whether these medications might serve a dual purpose