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While the discovery of rs4149056 in the SLCO1B1 transporter gene is an example of a significant and initially striking finding, several further studies have failed to replicate this finding in different cohorts (Puccetti et al., 2010

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Furthermore, it modulates immune responses by promoting the production of pro-inflammatory cytokines, accelerating neutrophil apoptosis, and inducing excessive neutrophil extracellular trap formation, which exacerbates lung tissue damage