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Vit-B12 is also an essential nutrient for skeletomusculargutbrain axis to maintain skeletal muscle, neuro-cognitive functions, and modulate gut microbiota 550,551

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Simultaneously, the IRAK-TRAF6 complex activates mitogen-activated protein kinase kinase (MKK) cascades, thus leading to activation of activator protein 1 (AP-1), which is another critical transcription factor in inflammation (50)

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