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Perinatal Epigenetic Signatures Perinatal imbalance in the metabolite contents of placenta versus umbilical cord blood, as well as dysregulated epigenetic signatures such as DNA methylation profiles, are correlated with ASD development in offspring

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Physiologically, insulin resistance and compensatory hyperinsulinemia in T2DM may attenuate the incretin effect of GLP-1 RAs through impaired insulin signaling or reduced GLP-1 receptor responsiveness