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In the colon, unabsorbed monosaccharides, polysaccharides, and non-digestible carbohydrates (fiber, resistant starch) are metabolized by bacterial fermentation into short-chain fatty acids [260,264]that bind free fatty acid receptors 2 and 3, resulting in GLP-1 secretion

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Many proteins contain small amounts of DPP-4 inhibitors, and amino acids that can trigger GLP-1 production

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