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It is common practice to measure the CL int of drugs in vitro using microsomes or hepatocytes to predict the in vivo CL (Lam and Benet, 2004

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doi: 10.3390/ijms20194673 46

1 Introduction Parkinsons disease (PD) ranks as the second most common neurodegenerative disorder, primarily manifesting through hallmark motor symptoms such as tremor, bradykinesia, postural instability, and rigidity, with non-motor symptoms including sleep disturbances, olfactory deficits, cognitive impairments, and depression often predating the motor manifestations (Madiha et al., 2021)

Current Research and Future Directions Ongoing studies continue to explore the full capabilities of AOD9604