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Heatmap analyses compared resistant and sensitive groups across several clinical and molecular features, including World Health Organization grade, age, gender, IDH mutation status, 1p/19q co-deletion status, and primary versus recurrent classification
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Below is a general timeline based on common clinical experience and published research, with the reminder that individual responses vary
To complement the Jadad score, the Cochrane Risk of Bias Tool (RoB 2) (Sterne et al., 2019) was also used for RCTs to provide a domain-based qualitative evaluation, assessing risks related to selection, performance, detection, attrition, and reporting
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