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53 , W547W553 (2025)

Furthermore, the study highlights that most trials have had extremely short follow-up periods (usually 824 weeks), which has hampered our understanding of the therapies long-term safety and sustained efficacy

The phosphorylated Gab1 creates additional binding sites for most downstream signaling molecules, which activate the different signaling pathways, including JAK/STAT3, phosphoinositide 3-kinase (PI3K)/Akt/NF-B, Ras/Raf, and mitogen-activated protein kinase (MAPK) cascades