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Anxiety, however, was slower to decrease, and opioid withdrawal required more DSIP injections over a longer period of time

People who undergo surgeries or dental procedures involving nitrous oxide, or who use the drug recreationally

The articles were collected, organized, and sorted using the Covidence software (Melbourne, Australia) for systematic review

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Statistical analyses As Pearson correlation coefficients between the nine metabolite concentration values (three metabolites in three voxels) were substantial even after adjustment for potential confounders, we used principal component analysis (PCA) to identify latent metabolite variables, and extracted scores for each component (see Results and SA7 for details)