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The most significant concern is liver toxicity, which requires monitoring

It has also been associated with toxicity in neonates

Funding This study was partially supported by The Ministry of Research, Technology and Higher Education, Republic of Indonesia

For patients with a naturally small cup-to-disc ratio, a structural characteristic of the optic nerve, the risk appears higher

As glutathione is the most abundant cellular thiol, its oxidation by free radicals to GS is a preponderant reaction, and the formation of GS is viewed as a toxicological event as this radical species abstracts H atoms from cellular molecules, reacts with sulfhydryls to form disulfides, and adds to double bonds 22,23