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A hallmark of ferroptotic initiation and execution is the upregulated peroxidation of phospholipid-bound polyunsaturated fatty acids (PUFAs) within cellular membranes, a process facilitated by labile iron pools (LIPs) and amplified through autocatalytic radical reactions (13,14)

Plusieurs complments interagissent positivement avec le GSH

Accessed June 2015

Over time, both forms experienced further reduction in the availability of amides for exchange, with Abeta-42 showing a faster timeline for reduction

The CGS is a pyridoxal 5-phosphate (PLP)-containing homo-tetramer that uses o -phosphohomoserine (derived from aspartate) and cysteine as substrates for cystathionine biosynthesis (Ravanel et al., 1998a)