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Nevertheless, the kinetic data for our mutants and rate constants for ScGrx7 and PfGrx between 10 5 10 6 M 1 s 1 are too slow for a diffusion-controlled reaction and point towards important short-lived enzymesubstrate interactions and rate-limiting re-orientations of the substrate at the enzyme surface

Case presentation Patient background: Age/gender: 33-year-old woman Symptoms: Right medial elbow pain persisting for one year following a minor trauma Previous treatment: Physical therapy and NSAIDs, with no significant improvement The patient reported ongoing pain in the medial aspect of her right elbow, which significantly affected her daily activities