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( B ) Schematic representation of IR/IGF1R DKO preadipocytes reconstituted with WT-IR and L973F mutated IR (L973F-IR)

696 Fer-1 can also reduce the accumulation of iron and ROS, downregulate the ferroptosis-related genes PTGS2 and their products, thereby inhibiting the ferroptosis of oligodendrocytes, and finally alleviating the white matter injury after SCI in rats and promoting functional recovery

10.1080/15504263.2021.2013096 11 CadeteV

A surrogate endpoint may reduce the duration length and cost of clinical trials and be a better indicator of drug efficacy with hematological indices better served as secondary endpoints