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When norepinephrine is released from LC neurons it activates both 1 and -adrenergic receptors in subcortical regions of the brain responsible for arousal

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Other studies have shown how low glutathione levels may be a risk factor for paracetamol hepatotoxicity in alcoholics because a lower dose of paracetamol will be necessary to deplete GSH below the critical threshold concentration where hepatocellular necrosis starts to occur