2 Mechanisms of action and ongoing therapeutic innovations in GLP-1 receptor agonists All GLP-1 RAs mimic the endogenous hormone GLP-1, binding to GLP-1 receptors (GLP-1 Rs) distributed in pancreatic islets, the gastrointestinal tract, and the brain
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Common injection sites include the abdomen, upper arms, and front of the thighs
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They may quiet "food noise." By influencing brain pathways tied to hunger, satiety and reward, GLP-1 drugs may reduce the intrusive, persistent thoughts about food that many people describe as "food noise." Researchers say some patients only realize how constant that mental chatter was once it noticeably quiets on the medication