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Abbreviations IGF-1: Insulin-like growth factor-1 GFBP 15 : Insulin-like growth factor binding proteins 15 BrCa: Breast cancer GH: Growth hormone IRS-1: Insulin receptor substrate 1 PI3K: Phosphatidylinositol 3-kinase MAPK: Mitogen-activated protein kinase ER-: Estrogen receptor - PR: Progesterone receptor SUMO: Small ubiquitin-like modifier BRCA1: Breast cancer 1-early onset protein KLF6: Kruppel-like factor 6 PARP1: Poly-ADP ribose polymerase 1 VHL: Von hippel lindau protein WT1: Wilms tumor 1 protein S6K1: Ribosomal protein S6 kinase 1 protein mTOR: Mammalian target of rapamyci HER2: Human epidermal growth factor receptor 2 protein SNP: Single-nucleotide polymorphism PBS: Phosphate buffer saline EMT: Epithelial to mesenchymal transition CTCs: Circulating tumor cells ECM: Extracellular matrix BD: Binding domain VEGFc: Vascular endothelial growth factor receptor c EGFR: Epidermal growth factor receptor TGF: Transforming growth factor UTRs: Untranslated regions EREL: Estrogen-responsive element-like site PGE2: Prostaglandin E2 ChIP: Chromatin immunoprecipitation COX-2: Cyclooxygenase-2 VN: Vitronectin ECR: Evolutionary conserved regions DFS: Disease-free survival TDLU's: Terminal duct lobular units BCSC: Breast cancer stem cell BCSS: BrCa-specific survival mAb: Monoclonal antibody RTKI: Receptor tyrosine kinase inhibitor IR: Insulin receptor References Ruan W, Kleinberg DL

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Kopp et al