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Though GLP-1R + cells are a relatively small subset of VSMCs, Glp1r VSM/ mice with Cre expression driven by the Myh11 promoter exhibit complete loss of immunofluorescence staining of GLP-1R in kidney sections and 95% knockdown of Glp1r mRNA expression in both renal artery and kidney (Figure 1)

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These may signal gastroparesis or bowel obstructionrare but serious complications requiring imaging and clinical assessment beyond self-management

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Because they may not understand when we say only 6%, 7% of adult Americans are metabolically healthy