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Although the mechanism(s) underlying NASH progression remain to be fully elucidated, accumulating evidence suggests that both oxidative stress and the pro-inflammatory cytokine tumor necrosis factor- (TNF) are critical contributors in this process 5

This convergence renders the NF-B and C/EBP pathways promising drug targets for the modulation of the SASP

Further, 34.7% achieved 25% loss, and 19.3% achieved 30% loss

The massive synthesis of pyruvate and the activation of the mTOR-HIF-1 pathway will further promote the aerobic glycolytic process, facilitating the TI process (134, 135)

The carcinogenic/toxic compounds from areca nut and tobacco have been used to study their binding affinity for homodimeric wild (GSTP1 Ile/Ile), homodimeric mutant (GSTP1 Val/Val) and heterodimeric mutant (GSTP1 Ile/Val) proteins