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Notably, tyrosinase possesses two copper ions, i.e., CuA and CuBcoordinate with six histidine (His) residues in the conserved catalytic pocket 14,15 , and are critically required to exhibit both types of enzymatic activities 6,16

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Enhanced tumor targeting and penetration of proteolysis-targeting chimeras through iRGD peptide conjugation: a strategy for precise protein degradation in breast cancer

Hambrecht-Wiedbusch et al., 2017

[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Aoyama K., Wang F., Matsumura N., Kiyonari H., Shioi G., Tanaka K., Kinoshita C., Kikuchi-Utsumi K., Watabe M., Nakaki T