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More recent studies of isolated acini from mouse and rat pancreas showed a small but dose dependent stimulation of amylase release comparable to that induced by VIP or secretin (54, 98)

66 In a randomized, controlled phase 3 study by Jastreboff et al, no difference in gallbladder stone rates was observed between 5, 10, and 15 mg tirzepatide treatment and placebo in obese individuals over 72 weeks

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The results of the Ramachandran plot indicated that the overall quality of the predicted models of the engineered fusion proteins is sufficiently good