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Dominant Region : North America remains the leading region owing to advanced healthcare systems, high diagnosis rates, and strong reimbursement for diabetes and obesity drugs

This orphan status has created a dichotomy in the scientific community: while empirical evidence from animal models and human clinical trials in the 1980s demonstrated significant therapeutic potential, particularly in addiction and stress management, the lack of a defined molecular pathway has stalled its development into a licensed pharmaceutical agent

The Raun 1998 paper is an animal study