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Stay consistent: Daily support is more effective than occasional high doses

They include hydroxyl (HO * ) and superoxide (O 2 * ) free radicals and nonradical molecules, such as hydrogen peroxide (H 2 O 2 ), which is less reactive than the majority of ROS but is able to reach any cellular compartment prior to being converted by peroxiredoxins and glutathione peroxidases into water and oxygen

Phase 1b/2 study of binimetinib (BINI) in combination with nivolumab (NIVO) or NIVO plus ipilimumab (IPI) in patients (pts) with previously treated microsatellite-stable (MSS) metastatic colorectal cancer (mCRC) with RAS mutation

Despite advancements in treatment, a definitive cure remains out of reach, as current approaches mainly focus on managing underlying conditions

Outstanding challenges and opportunities for further innovation are discussed