Available data on pediatric populations show controversial results, ranging from the absence of relevant changes in anti-seizure drugs' blood concentration (15) to subtle changes in topiramate, levetiracetam, phenobarbital, and carbamazepine and possibly significant changes in valproate concentration under the influence of KDT (16)
A Paragraph IV filing on a high-value drug typically precedes actual generic availability by three to five years in contested cases
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