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This bioactive molecule originates from catechin or epicatechin units which in turn constitute procyanidins that are highly abundant in the French maritime pine bark extract Pycnogenol (see sections 1.2.2 Pharmacodynamics, 4.1 Absorption into plasma/serum and concentration profiles, 5 Biodistribution, and 6.1 Pre-systemic metabolism: role of gut microbiota)

Moreover, stressed melanocytes undergo apoptosis and secrete melanocyte-specific antigens and immunostimulatory signals such as cytokines (IL-6 and IL8) (Colucci et al., 2015)

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