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Published research, including trials in the New England Journal of Medicine, has shown tirzepatide producing greater average weight loss in head-to-head comparisons with semaglutide, with some study participants losing 20% or more of their body weight

Few other studies in the literature also have reported significant color changes over a period of time

[9] Bone remodeling markers rise before density itself changes, so this was an early biomarker signal rather than proof of fracture-relevant benefit a distinction reinforced by the hip-fracture trial discussed below, which failed to show functional benefit

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Watt TMF, Kleeman KC, Brescia AA, Seymour EM, Kirakosyan A, Khan SP, et al