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Inoue K, Yamasaki S, Fushiki T, Kano T, Moritani T, Itoh K, Sugimoto E

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One of the peptides most intriguing roles is its impact on the hypothalamic-pituitary-adrenal (HPA) axis, where it modulates the secretion of adrenocorticotropic hormone (ACTH) and cortisol

NOX inhibition targets NADPH oxidases at the plasma membrane and within organelles: using selective NOX1/4 blockers or broader pan-NOX agents can dampen site-specific ROS generation, which in turn may slow fibrotic remodeling, protect endothelial function and vascular tone, and ease downstream metabolic stress

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