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doi:10.2169/internalmedicine.54.2710

Valado PAC, Santos KBS, Ferreira e Vieira TH, Macedo e Cordeiro T, Teixeira AL, Guatimosim C, et al

Herv F, Ghinea N, Scherrmann JM

The fundamental principle involves delivering active compounds through the skin directly into systemic circulation, bypassing the gastrointestinal tract and first-pass hepatic metabolism

Side Effect Management Both compounds have established side effect profiles from clinical trials