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In the Falutz 2010 trials, once-daily dosing at 2 mg produced mean IGF-1 increases that normalized toward baseline over the 26-week trial, suggesting some receptor adaptation without complete desensitization

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Hernandez A, Levi H, Juncos JXM, et al

For best results : clients add the other treatments as well

42 The mechanisms of these complex effects are still being elucidated, and it is unclear whether there is a direct effect via GLP-1 receptors in bone cells or indirect effects mediated through the gut