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Studies show that patients losing 510% of body weight may experience changes in their INR (international normalized ratio) if taking warfarin, or altered drug exposure with direct oral anticoagulants

This means contraception becomes essential if pregnancy is not desired, as ovulation may resume unexpectedly

Its like, OK, now my partner is getting more attention, are they going to leave me? These are issues that Mackintosh says he has seen resolved in secure, functioning relationships through communication and acceptance

Commonly Reported Side Effects The most frequently observed adverse events in the Phase 2 trial were gastrointestinal in nature, including nausea, vomiting, diarrhea, and constipation