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Palmitoyl tripeptide-1 addresses the stimulation side but not the copper-dependent protection side

After washing in PBS, the fixed samples were pre-embedded into 2% agar, cut vertically, put in transwells side face up, embedded again in paraffin blocks and sectioned

Tissue collectionAt the time of scheduled termination, animals are sacrificed as follows

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These mice lacking periaxin develop clear evidence of impaired axonal integrity, such as reduced axonal diameters, a progressively reduced total number of axons, and a considerable number of myelin whorls lacking a visible axon