The transient elevation of peripheral cytokines, such as IL-6 induces sustained effects through the following mechanisms: 1) Activated microglia can sustain a pro-inflammatory phenotype over extended periods, thereby potentially becoming a continuous source of IL-1 and TNF- within the central nervous system (127, 128)
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In: De Simone C, Martelli EA (eds) Stress, Immunity and AgeingA Role for Acetyl- L carnitine Excerpta Medica: Amsterdam 1989
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Your doctor establishes the appropriate dosage, taking into account your weight and overall health