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In some embodiments, a formulation described herein, further comprises a gelling agent (e.g., poloxamer 407) and provides release of the therapeutic agent over a period of from about 1 day to about 5 days

and the detailed 3D structures and binding interface analysis were visualized by PyMOL v2.5.4

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The practical rationale for combination protocols is straightforward: BPC-157 targets local tissue repair (particularly GI, musculoskeletal, and neural) through signaling pathways that promote growth factor expression and cell survival at injury sites, while TB-500 operates more systemically particularly through vascular remodeling, cardiac progenitor activation, and direct anti-inflammatory cytokine modulation

10.1007/s00595-007-3706-2 80 NowakK