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So, we think this is a key area to monitor over the coming months from a European competitiveness standpoint, Alvaro Serrano: I think that's a great place to wrap it up

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Hypoxia-induced senescence of PASMCs releases IL-6 via the mTOR/S6K1 pathway, and paracrine signals activate the metabolic-inflammatory network in adjacent cells, forming a metabolism-driven effect of senescence-associated secretory phenotype (Wang et al., 2021)