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Although some GLP-1 RAs can cross the blood-brain barrier (BBB) and may exert neuroprotective effects 64 , the extent and mechanisms of these effects remain incompletely understood

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To help with any discomfort, you can use cold packs on the area

At the same time, sustained receptor engagement may induce adaptive responses such as receptor desensitization, endocrine feedback suppression, or compensatory pathway activation

Mucosa doesnt offer the same kind of barrier that skin does, Dr