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Theres no regulation requiring proof
Fallacy 5: Homocysteine Should Always Be as Low as Possible Raised homocysteine is associated with an increased risk of numerous chronic diseases and, in most circumstances, lowering an elevated level is beneficial
If both are elevated, the inflammatory signal is stronger
AHFS Drug Information, 2012
The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison
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