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Phytomedicine 2023, 108, 154520 10.1016/j.phymed.2022.154520
It works by improving insulin sensitivity, activating AMPK (an enzyme that boosts fat burning), and enhancing mitochondrial function to increase overall energy production
Induction of these chaperones represents an adaptive stress response that protects cardiomyocytes by stabilizing the contractile apparatus and preserving sarcomeric organization during ischemic injury
In NAD + -depleted states (e.g., aging or advanced disease), SIRT1 activation consumes residual NAD + , impairing NAD + -dependent repair enzymes such as PARPs, and increasing oxidative stress
10.1152/ajplegacy.1971.221.4.1038 188 KlauserR.PragerR.GaubeS.GisingerC.SchnackC.KuenburgE.et al (1991)
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