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Per the applicant, the aprevo Cervical ACDF System is a personalized interbody cage that is implanted using an anterior surgical approach, which matches the descriptor for C1831 (interbody cage, anterior, lateral or posterior, personalized (implantable))

Since our proteomic study suggested mitochondrial alterations following HC treatment, and considering the recent hypothesis of Simeone (Simeone, 2025) that HC might interact with key cellular antioxidant systems, mitochondrial function was further investigated through oxygen consumption rate (OCR), extracellular acidification rate (ECAR), mitochondrial membrane potential, mitochondrial network morphology, ROS production and GSH/GSSG ratio

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As the inflammatory response progresses, a glial scar is formed around the injury, consisting mostly of proteoglycans and reactive astrocytes