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Association of cultured myotubes and fasting plasma metabolite profiles with mitochondrial dysfunction in type 2 diabetes subjects

12 Replacement of GLP-1 His 7 with Phe 7 does not influence either its receptor affinity or cAMP activity, indicating that the aromaticity of His is crucial to its activity

3,4 Incretin-based therapies and SGLT-2 inhibitors have an ever- increasing emphasis within clinical guideline recommendations and are, therefore, increasingly utilized in clinical practice

Currently, except for LIR and SMG, the numbers of related clinical studies of other GLP-1R agonists are few, especially in obese or overweight people without diabetes