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These changes can be categorized broadly into global/repetitive element methylation, gene-specific methylation, miRNA methylation, epigenetic clock genes alterations (see above), and methylation of immune- and retroviral-related elements 204

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These include people with type 2 diabetes or higher blood sugar, people with a history of cancer, and people with eye conditions like diabetic retinopathy

Reading the mechanism this way copper first, everything else downstream is also what keeps the safety discussion honest, because the very property that makes the biology interesting is the property that creates the systemic risk