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An additional 202 articles were excluded for the following reasons: irrelevant study population (n=60), unrelated interventions (n=90), insufficient or incomplete data (n=52), and language limitations (non-English)

After this 1:1 matching, the final study population included 57,456 participants, with 28,728 individuals in each treatment group

This loop significantly amplifies renal sympathetic nerve activity and exacerbates sympathetic hyperactivity (Wang et al., 2024), providing a novel mechanism for aging-related cardiac dysfunction

Furthermore, clinicians need to consider ethical concerns

Individuals with a personal or strong family history of medullary thyroid cancer, multiple endocrine neoplasia type 2, or active pancreatitis should not take these medications