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Others have demonstrated that the positive outcomes of obesity surgery (i.e., changes in body weight and improved glucose homeostasis) are sustained in mice in the absence of GLP-1R or Y2-R, or both GLP-1R and Y2-R 66,67

Cao C, Yang S, Zhou Z

So is it fixing something that in some people, for whatever reason we don't understand, that signaling is not working the way it's supposed to

Areas Requiring Further Investigation Further research is needed to clarify long-range receptor signaling behavior, tissue-specific pathway effects, molecular signaling durability, model-to-human translation, and how findings vary across study designs

However, In patients with T2DM, oral semaglutide showed better glycemic control than placebo over 26 weeks [48]