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doi:10.1016/j.hlc.2021.09.006 220
Genes related to the Fenton reaction included those associated with the Warburg effect and proliferation, cytosolic iron-sulfur cluster synthesis, neutralization of HO, NADPH-dependent dehydrogenases, exogenous superoxide synthesis, cytosolic iron transporters, the proteasome, the oxidative-to-glycolytic shift, the Warburg effect, and central carbon metabolism in cancer obtained from KEGG database ( Other gene lists were custom-designed to capture broader biological processes and disease-relevant pathways
There is a consensus that various types of cancer may arise from interactions between free radicals and DNA, leading to genotoxic damage
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