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These criteria reflect clinical evidence showing that GLP-1 therapy works best in people with metabolic risk factors rather than as a general weight-loss tool

One of the most documented concerns with GLP-1 receptor agonist therapy is the loss of lean body mass during treatment

If you're not experiencing expected hunger reduction after six weeks at a stable dose, your provider may recommend advancing to the next dose tier or exploring whether genetic factors (tested through PlexusDx's Precision Peptide Genetic Test) influence your peptide pathway response

Without structure around training and nutrition, the trade-off can quietly work against long-term health

instead, a precision medicine approach should integrate additional factors such as the trajectory of eGFR, biomarkers of tubular injury, imaging findings and the presence of co-morbid conditions [50,51,52]