The beneficial effect of tirzepatide on hsCRP, a biomarker of systemic inflammation, YKL-40, a proinflammatory cytokine, and ICAM-1, a biomarker of endothelial dysfunction, was already detectable at 4 weeks, consistent with the salutary effects of GIP and GLP-1 on inflammation and atherosclerosis in experimental models [84,85,86]
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GLP-1 receptor agonists stimulate glucose-dependent insulin secretion and suppress appetite, whilst metformin reduces hepatic glucose production and enhances insulin sensitivity
severe hepatic impairment, n = 4) at two sites in Slovakia and one in Germany between 5 April 2023 and 19 December 2024 (Supplementary Table S1)
