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Finally, we discuss translational gaps including scalability, regulatory hurdles, and patient-specific variability that must be addressed for successful clinical implementation

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Until recently, the treatment of mild GO was typically limited to local measures (19 but ~15% of patients GO progress to an extent that requires specific treatments (13, 58)

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In a Several studies included in this review also found that acetyl-L-carnitine was as effective as antidepressant medications but caused fewer adverse effects