288 Existing studies have demonstrated that L-DON and JHU-083 can extensively inhibit Gln metabolizing enzymes and activate AMPK and c-Myc to inhibit glycolysis, thereby stopping tumor metabolic activity, alleviating hypoxia, and increasing the concentration of Gln and glucose in TME
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PubChem Compound Summary for CID 9941957 PubChem, Gurtner GC, Werner S, Barrandon Y, Longaker MT