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Firstly, we discussed the epidemiology and various risk factors such as genetic mutations ( BRCA1/2, TP53, PTEN ), hormonal influences, several lifestyle risk factors (obesity, smoking, etc.), and environmental factors (chemical exposure, air pollutants, etc.)

Ramsey, and C.S

Journal of Forensic and Legal Medicine 2011

Uterine immune dysregulation, including altered uNK abundance and functional imbalance, impaired macrophage-associated remodeling at the decidualtrophoblast boundary, and insufficient expansion of regulatory T cells, has been repeatedly implicated in early pregnancy loss [375,376,377]

Bladders were extracted, weighed, fixed in 4% PFA for 24 h, and then embedded in paraffin for histopathological analysis