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In cases of overdose of alpha lipoic acid, some patients have developed lactic acidosis, hemodynamic instability, rhabdomyolysis, renal dysfunction, and multiorgan failure, but symptoms of neurologic, cardiac and renal dysfunction generally predominate and liver injury may be the result of shock and ischemia

The result is a compound that attacks obesity from angles that dual agonists simply cannot reach

NPY truncated forms are especially active at the Y2 receptor, whereas lose efficacy at the Y1 receptor